Skip to main content
Fig. 6 | BMC Evolutionary Biology

Fig. 6

From: Cysteine boosters the evolutionary adaptation to CoCl2 mimicked hypoxia conditions, favouring carboplatin resistance in ovarian cancer

Fig. 6

ES2 (OCCC) and OVCAR3 (OSC) cells present different dynamics of response to carboplatin. Cells response to Carboplatin over time for a. ancestral ES2 cells and OVCAR3 cells, b. ES2 and OVCAR3 cells selected under normoxia, c. ES2 and OVCAR3 cells selected under hypoxia mimicked with CoCl2. N – Normoxia; NC – Normoxia supplemented with cysteine; H – Hypoxia mimicked with CoCl2; HC – Hypoxia mimicked with CoCl2 supplemented with cysteine. Data were normalized to the respective control. Results are shown as mean ± SD. *p < 0.05, **p < 0.01, ***p < 0.001 (One-way ANOVA with post hoc Tukey tests)

Back to article page