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Fig. 5 | BMC Evolutionary Biology

Fig. 5

From: Cysteine boosters the evolutionary adaptation to CoCl2 mimicked hypoxia conditions, favouring carboplatin resistance in ovarian cancer

Fig. 5

ES2 cells tend to present a stronger response to carboplatin than OVCAR3 cells. Comparison of ES2 amd OVCAR3 cells response to carboplatin for 48 h of experimental conditions for a. ancestral ES2 and OVCAR3 cells. b. ES2 and OVCAR3 cells selected under normoxia and c. ES2 and OVCAR3 cells selected under hypoxia mimicked with CoCl2. N – Normoxia; NC – Normoxia supplemented with cysteine; H – Hypoxia mimicked with CoCl2; HC – Hypoxia mimicked with CoCl2 supplemented with cysteine. Data were normalized to the respective control. Results are shown as mean ± SD. *p < 0.05, **p < 0.01, ***p < 0.001 (Independent samples T test)

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