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Fig. 2 | BMC Evolutionary Biology

Fig. 2

From: Cysteine boosters the evolutionary adaptation to CoCl2 mimicked hypoxia conditions, favouring carboplatin resistance in ovarian cancer

Fig. 2

Proliferation rate of ES2 (OCCC) and OVCAR3 (OSC) cells selected under normoxia and under CoCl2 mimicked hypoxia. a. Proliferation curve for ES2 cells, b. Cell cycle analysis for ES2 cells for 48 h of assay, c. Proliferation curve for OVCAR3 cells, and d. Cell cycle analysis for OVCAR3 cells for 48 h of assay. NN – cells selected under normoxia and cultured under normoxia; NH – cells selected under normoxia and cultured under CoCl2 mimicked hypoxia; HN – cells selected under hypoxia and cultured under normoxia; HH – cells selected under CoCl2 mimicked hypoxia and cultured under CoCl2 mimicked hypoxia. Asterisks represent statistical significance in comparison with cells selected under normoxia and cultured under normoxia (NN). Cardinals represent statistical significance in comparison with cells selected under normoxia and cultured under hypoxia (NH). *p < 0.05, **p < 0.01, ***p < 0.001 (One-way ANOVA with post hoc Tukey tests)

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