From: The evolution of a series of behavioral traits is associated with autism-risk genes in cavefish
# orthologs of SFARI Gene that express differently (up or down) | Transcriptome from the cortices of ASD patients (Voineagu et al., 2011) | Transcriptomes from multiple tissues of ASD patients (review: Ansel et al., 2017) | Transcriptome from the cortices of ASD patients (Parikshak et al., 2016) | |
---|---|---|---|---|
A. mexicanus
(Whole Embryo 10–72 hpf) Reanalyzed in this study | 335 of 409† (81.9%) |
43‡ of 58 orthologs expressed differently between CF and SF (74.1%) |
51‡§ of 77 orthologs expressed differently between CF and SF (66.2%) |
2567‡ of 3442 orthologs expressed differently between CF and SF (74.6%) |
31 of 51‡ genes expressed in the same direction: (60.7%) |
27 of 45‡§ directionally expressed genes are in the same direction: (60.0%) |
1843 of 3152‡ directionally expressed genes are in the same direction: (58.5%) | ||
BTBR Mouse (Hippocampus) Provenzano et al., 2016 | 30 of 493 (6.1%) |
2 of 65 orthologs expressed differently in BTBR mouse (3.0%)a |
9§ of 105 orthologs expressed differently in BTBR mouse (8.6%)b |
216 of 4042 orthologs expressed differently in BTBR mouse (5.3%)c |
0 of 2 genes expressed in the same direction (0.0%) |
4 of 7§ directionally expressed genes are in the same direction (57.1%) |
109 of 216 directionally expressed genes are in the same direction (50.5%) | ||
ASD patients (Blood) Pramparo et al., 2015 | 51 of 493 (10.3%) |
11 of 65 human genes expressed differently in ASD patient’s blood (16.7%)d |
16§ of 107 human genes expressed differently in ASD patient’s blood (14.8%)e |
485 of 4425 human genes expressed differently in ASD patient’s blood (11.0%)f |
7 of 11 genes expressed in the same direction (63.6%) |
4 of 7§ directionally expressed genes are in the same direction (57.1%) |
179 of 485 directionally expressed genes are in the same direction (36.9%) | ||
Neural cells derived from iPS cell of ASD patient Mariani et al., 2015 |
95 of 493 (19.3%) |
18 of 65 of human genes expressed differently in neurons derived from iPS cells of ASD patients (27.7%)g |
21§ of 107 human genes expressed differently in neurons derived from iPS cells of ASD patients (19.6%)h |
527 of 4425 human genes expressed differently in neurons derived from iPS cells of ASD patients (11.9%)i |
0 of 18 human genes expressed in the same direction (0%) |
1 of 16§ directionally expressed genes are in the same direction (6.3%) |
163 of 527 directionally expressed genes are in the same direction (30.9%) |