From: The evolution of a series of behavioral traits is associated with autism-risk genes in cavefish
# orthologs of SFARI Gene that express differently (up or down) | Transcriptome from the cortices of ASD patients (Voineagu et al., 2011) | Transcriptomes from multiple tissues of ASD patients (review: Ansel et al., 2017) | Transcriptome from the cortices of ASD patients (Parikshak et al., 2016) | |
---|---|---|---|---|
A. mexicanus (Whole Embryo 10–72 hpf) Reanalyzed in this study | 335 of 409† (81.9%) | 43‡ of 58 orthologs expressed differently between CF and SF (74.1%) | 51‡§ of 77 orthologs expressed differently between CF and SF (66.2%) | 2567‡ of 3442 orthologs expressed differently between CF and SF (74.6%) |
31 of 51‡ genes expressed in the same direction: (60.7%) | 27 of 45‡§ directionally expressed genes are in the same direction: (60.0%) | 1843 of 3152‡ directionally expressed genes are in the same direction: (58.5%) | ||
BTBR Mouse (Hippocampus) Provenzano et al., 2016 | 30 of 493 (6.1%) | 2 of 65 orthologs expressed differently in BTBR mouse (3.0%)a | 9§ of 105 orthologs expressed differently in BTBR mouse (8.6%)b | 216 of 4042 orthologs expressed differently in BTBR mouse (5.3%)c |
0 of 2 genes expressed in the same direction (0.0%) | 4 of 7§ directionally expressed genes are in the same direction (57.1%) | 109 of 216 directionally expressed genes are in the same direction (50.5%) | ||
ASD patients (Blood) Pramparo et al., 2015 | 51 of 493 (10.3%) | 11 of 65 human genes expressed differently in ASD patient’s blood (16.7%)d | 16§ of 107 human genes expressed differently in ASD patient’s blood (14.8%)e | 485 of 4425 human genes expressed differently in ASD patient’s blood (11.0%)f |
7 of 11 genes expressed in the same direction (63.6%) | 4 of 7§ directionally expressed genes are in the same direction (57.1%) | 179 of 485 directionally expressed genes are in the same direction (36.9%) | ||
Neural cells derived from iPS cell of ASD patient Mariani et al., 2015 | 95 of 493 (19.3%) | 18 of 65 of human genes expressed differently in neurons derived from iPS cells of ASD patients (27.7%)g | 21§ of 107 human genes expressed differently in neurons derived from iPS cells of ASD patients (19.6%)h | 527 of 4425 human genes expressed differently in neurons derived from iPS cells of ASD patients (11.9%)i |
0 of 18 human genes expressed in the same direction (0%) | 1 of 16§ directionally expressed genes are in the same direction (6.3%) | 163 of 527 directionally expressed genes are in the same direction (30.9%) |