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Table 2 Top 10 GO annotation clusters for three protein groups with different dN/dS estimates

From: Correlates of evolutionary rates in the murine sperm proteome

“Low dN/dS”

“Medium dN/dS”

“High dN/dS”

Cluster description (enrichment score)

Cluster description (enrichment score)

Cluster description (enrichment score)

Protein localization

(18.69)

Protein localization

(7.84)

(Male) reproduction

(5.99)

Protein localization

(13.68)

tRNA metabolism

(7.75)

Membrane lipid catabolism

(3.51)

Macromolecular complex assembly

(8.14)

TCA cycle

(4.85)

Sperm-egg interaction

(3.42)

(m)RNA processing

(8.07)

ATP synthesis

(3.95)

Sugar catabolism

(3.11)

Protein catabolic process

(7.85)

Porphyrin biosynthesis

(3.39)

Response to oxidative stress

(2.64)

Protein complex assembly

(5.58)

Protein complex assembly

(3.12)

Protein localization

(2.31)

Regulation of protein complex assembly

(3.71)

Sugar catabolism

(2.91)

Porphyrin biosynthesis

(2.09)

ATP synthesis

(3.63)

Protein localization

(2.89)

Regulation of lipid transport

(2.02)

Sugar catabolism

(3.59)

Cytoskeleton organization

(2.43)

Lipid metabolism/catabolism

(1.90)

Sugar metabolism

(3.29)

(m)RNA transport

(2.37)

Chemical homeostasis

(1.79)

  1. For a description of the three protein groups, see Methods. Names of clusters were assigned by the authors based on results of enrichment analyses with DAVID (version 6.7)