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Table 4 Summary of DRB variation in the three R. roxellana populations

From: High polymorphism in MHC-DRB genes in golden snub-nosed monkeys reveals balancing selection in small, isolated populations

Locus

Pop

N

k

Nu

Co

ABS

Variable nucleotide positons

Variable codons

Variable ABS

PIS

Probability test

P null

A R

PIC

A E

H E

H O

Overall mean distance

F IS

Tajima’s D (P-value)

DRB1

FP

32

6

243

81

18

48

29

16

27

0.034 ± 0.000

−0.010

5.994

0.542

2.338

0.581

0.563

0.101 ± 0.015

0.033

0.643(P > 0.10)

NS

36

7

243

81

18

54

29

16

26

0.170 ± 0.000

0.072

6.993

0.606

2.692

0.637

0.583

0.105 ± 0.015

0.086

0.519(P > 0.10)

ZZ

54

8

243

81

18

54

30

16

41

0.038 ± 0.000

0.026

6.899

0.701

3.878

0.749

0.703

0.111 ± 0.014

0.061

1.062(P > 0.10)

All

122

11

243

81

18

60

30

16

43

–

–

8.030

0.665

2.969

0.697

0.631

0.104 ± 0.015

–

0.977(P > 0.10)

DRB2

FP

30

4

243

81

18

37

19

8

8

0.109 ± 0.000

−0.056

4.000

0.479

2.064

0.524

0.533

0.092 ± 0.019

0.000

0.506(P > 0.10)

NS

36

6

243

81

18

40

22

11

22

0.368 ± 0.001

0.065

5.993

0.589

2.618

0.627

0.583

0.082 ± 0.014

0.070

0.564(P > 0.10)

ZZ

53

6

243

81

18

42

21

11

18

0.000 ± 0.000a

0.202

5.530

0.579

2.730

0.640

0.415

0.084 ± 0.016

0.353

0.326(P > 0.10)

All

122

8

243

81

18

44

23

12

28

–

–

6.352

0.584

2.471

0.621

0.496

0.082 ± 0.014

–

0.608(P > 0.10)

  1. Pop population, N number of genotyped samples, k number of alleles, Nu nucleotides, Co codons, PIS parsimony-informative sites; Probability test were apply for testing deviation from the Hardy-Weinberg equilibrium (HWE); Pnull, the frequency of null alleles; AR, allelic richness; PIC, polymorphic information content; AE, effective number of alleles; HO and HE, observed and expected heterozygosity, respectively; the overall mean distance here was applied to the nucleotide sequence; FIS, inbreeding coefficient
  2. a, Excess of homozygotes at DRB2 locus for ZZ population