Fig. 2

mRNA of equine CEACAMs. From all indicated CEACAMs the genomic exon structure is shown on top and below the different transcript variants observed in this study were depicted. Differential splicing was found for CEACAM1 (4 transcripts), CEACAM41, CEACAM45 and CEACAM54 (each 2 different transcripts). Transcripts coding for secreted CEACAMs were found for CEACAM41 and CEACAM54. No transcript coding for a CEACAM with an ITAM signaling motif was identified. Transcripts coding for CEACAMs with ITIM/ITSM motifs were found only for two CEACAM genes. The majority of transcripts code for CEACAMs with a short cytoplasmic tail lacking immunotyrosine-based motifs. No indication for GPI-anchored CEACAMs was found. Red stars indicate the presence of a stop codon, mutated splice sites are marked with a red tilde