Evolution of CYP2J19, a gene involved in colour vision and red coloration in birds: positive selection in the face of conservation and pleiotropy

Table 3 Site-specific comparisons for 9 CYP loci in 25 avian species

	LRT Statistic		p-value		Corrected p-value		M2a			M8
CYP gene	M1a- M2a	M7-M8	M1a- M2a	M7-M8	M1a- M2a	M7-M8	Freq of sites with ω > 1	ω > 1	Positively selected sites under BEB P > 95% (bold: P > 99%)	Freq of sites with ω > 1	ω > 1	Positively selected sites under BEB P > 95%(bold: P > 99%)
CYP2J19	4.577	49.376	0.101	0.000		0.000^*	0.018	1.944		0.083	1.387	8, 37, 233, 455
CYP2J40	76.397	84.911	0.000	0.000	0.000^*	0.000^*	0.038	2.974	56, 59, 60, 61, 80, 247, 250, 393	0.056	2.246	56, 59, 60, 61, 80, 247, 250, 393
CYP19A1	0.000	3.579	1.000	0.167			0.020	1.000		0.011	1.031
CYP7A1	0.000	9.871	1.000	0.007		0.065	0.030	1.000		0.062	1.331
CYP8B1	11.835	46.986	0.003	0.000	0.024^*	0.000^*	0.028	2.170		0.101	1.506	104
CYP4V2	57.130	64.122	0.000	0.000	0.000^*	0.000^*	0.031	3.160	31, 67, 69, 75, 272	0.043	2.603	31, 57, 67, 69, 75, 145, 272
CYP3A9	57.980	86.997	0.000	0.000	0.000^*	0.000^*	0.059	2.504	88, 95, 135, 149, 203, 279, 466	0.081	2.095	4, 87, 88, 95, 135, 149, 203, 223, 279, 309, 466, 470
CYP7B1	8.154	25.295	0.017	0.000	0.153	0.000^*	0.017	2.468		0.023	2.220	89, 348, 437, 458
CYP20A1	0.000	5.957	1.000	0.051			0.047	1.000		0.014	1.833

Underlined sites fall within predicted functional domains for CYP2 proteins annotated in Almeida et al. 2016 [22]
*Significant result at p < 0.05 after p-value correction for multiple testing

ISSN: 2730-7182