Table 2 Pairwise interactions in the network involving genes/proteins from the catalog
| Â | Short name of the interaction | Description | Node 1 | Node 2 | Data source | Number of interactions in the network |
|---|---|---|---|---|---|---|
1. | PIs involving TBEV | Physical interactions between viral proteins or RNA or the whole TBEV particle and host proteins | The whole TBEV particle, or viral proteins or viral RNA | Human gene/protein from the catalog | Research articles | 51 |
2. | Up- or down-regulation | The effects of the whole TBEV particle or viral RNA or TBEV proteins on the expression levels of the host mRNA or proteins | The whole TBEV particle, or viral proteins or viral RNA | Human gene/protein from the catalog | Research articles | 76 |
3. | Associations | Associations of allelic variants in human genes with susceptibility or resistance to TBEV infection | The object TBEV susceptibility/resistance | Human gene/protein from the catalog | Research articles | 9 |
4. | PPIs affecting response | Physical interactions with proteins from the catalog affecting the biological response to TBEV | Human gene/protein from the catalog | Human gene/protein from the catalog | Research articles | 4 |
5. | Interaction within pathway | Indirect interaction with proteins from the catalog within the same signaling pathway affecting the biological response to TBEV | Human gene/protein from the catalog | Human gene/protein from the catalog | Research articles | 2 |
6. | Knockout | The effect of a gene knockout on the survival time after TBEV infection or disease manifestations | The object Knockout | Human gene/protein from the catalog | Research articles | 6 |
7. | PPI_STRING (Additional file 1: Table S7) | Physical interactions between genes/proteins from the catalog obtained from STRING and passed manual verification | Human gene/protein from the catalog | Human gene/protein from the catalog | STRING and Research articles | 25 |