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Table 2 Pairwise interactions in the network involving genes/proteins from the catalog

From: A database of human genes and a gene network involved in response to tick-borne encephalitis virus infection

  Short name of the interaction Description Node 1 Node 2 Data source Number of interactions in the network
1. PIs involving TBEV Physical interactions between viral proteins or RNA or the whole TBEV particle and host proteins The whole TBEV particle, or viral proteins or viral RNA Human gene/protein from the catalog Research articles 51
2. Up- or down-regulation The effects of the whole TBEV particle or viral RNA or TBEV proteins on the expression levels of the host mRNA or proteins The whole TBEV particle, or viral proteins or viral RNA Human gene/protein from the catalog Research articles 76
3. Associations Associations of allelic variants in human genes with susceptibility or resistance to TBEV infection The object TBEV susceptibility/resistance Human gene/protein from the catalog Research articles 9
4. PPIs affecting response Physical interactions with proteins from the catalog affecting the biological response to TBEV Human gene/protein from the catalog Human gene/protein from the catalog Research articles 4
5. Interaction within pathway Indirect interaction with proteins from the catalog within the same signaling pathway affecting the biological response to TBEV Human gene/protein from the catalog Human gene/protein from the catalog Research articles 2
6. Knockout The effect of a gene knockout on the survival time after TBEV infection or disease manifestations The object Knockout Human gene/protein from the catalog Research articles 6
7. PPI_STRING
(Additional file 1: Table S7)
Physical interactions between genes/proteins from the catalog obtained from STRING and passed manual verification Human gene/protein from the catalog Human gene/protein from the catalog STRING and Research articles 25