Fig. 3

Selected examples of confidently supported subtrees of Cas4 associated with different subtypes of CRISPR-Cas effector complexes. Strongly supported (support values indicated in red) subtrees correspond to branches from the complete Cas4 tree shown in Additional file 1: Figure S1 and available in Newick format as Supplementary Information File 1.Each sequence is denoted by a numeric identifier, matching those in Additional file 7: Table S1, subtype of the CRISPR-Cas system from the respective locus and species name. Several branches were collapsed and are indicated by triangles with CRISPR-Cas system subtype indicated next to respective triangle. The coloring of the sequences corresponds to distinct CRISPR-Cas system types or subtypes according to the color code provided at the bottom