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Table 2 Estimation of mutation supply during experimental evolution

From: The path to re-evolve cooperation is constrained in Pseudomonas aeruginosa

Iron availability Population bottleneck [CFU] Number of cell divisionsa Expected number of mutation eventsb
at specific nucleotide in pvdS anywhere in pvdS locusc
Low 5.0 × 104 1.2 × 1010 12.3 8.2 × 104
Medium 1.3 × 105 3.1 × 1010 30.9 20.6 × 104
High 2.8 × 105 6.8 × 1010 67.8 45.1 × 104
  1. aacross all replicate populations and 20 transfers
  2. bassuming a mutation rate of ~10-9 per nucleotide per cell division for P. aeruginosa PAO1 [32]
  3. c pvdS gene and upstream promoter region consisting of 666 bp