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Table 1 Selected KEGG pathways significantly enriched for up-regulated genes in sugar-only diet (SD) versus normal diet (ND)

From: Phenotypes, antioxidant responses, and gene expression changes accompanying a sugar-only diet in Bactrocera dorsalis (Hendel) (Diptera: Tephritidae)

KEGG pathway

Pathway ID

DEGs (668)

P-value

Level 1

Level 2

Oxidative phosphorylation

ko00190

66 (9.88%)

3.81e-41

Metabolism

Energy metabolism

Metabolic pathways

ko01100

159 (23.8%)

2.41e-10

Metabolism

Global and overview maps

Gastric acid secretion

ko04971

22 (3.29%)

1.51e-09

Organismal Systems

Digestive system

Oxytocin signaling pathway

ko04921

28 (4.19%)

1.71e-09

Organismal Systems

Endocrine system

Citrate cycle (TCA cycle)

ko00020

17 (2.54%)

2.21e-09

Metabolism

Carbohydrate metabolism

Calcium signaling pathway

ko04020

25 (3.74%)

2.86e-06

Environmental Information Processing

Signal transduction

MAPK signaling pathway

ko04010

29 (4.34%)

2.82e-05

Environmental Information Processing

Signal transduction

Dopaminergic synapse

ko04728

19 (2.84%)

0.000151

Organismal Systems

Nervous system

Leukocyte transendothelial migration

ko04670

28 (4.19%)

0.000163

Organismal Systems

Immune system

Folate biosynthesis

ko00790

9 (1.35%)

0.000292

Metabolism

Metabolism of cofactors and vitamins

Biosynthesis of amino acids

ko01230

14 (2.1%)

0.00158

Metabolism

Global and overview maps

Biosynthesis of antibiotics

ko01130

3 (4.64%)

0.00213

Metabolism

Global and overview maps

Alanine, aspartate and glutamate metabolism

ko00250

8 (1.2%)

0.00281

Metabolism

Amino acid metabolism

Metabolism of xenobiotics by cytochrome P450

ko00980

13 (1.95%)

0.00401

Metabolism

Xenobiotics biodegradation and metabolism

Aminobenzoate degradation

ko00627

9 (1.35%)

0.00505

Metabolism

Xenobiotics biodegradation and metabolism

Drug metabolism - cytochrome P450

ko00982

13 (1.95%)

0.00561

Metabolism

Xenobiotics biodegradation and metabolism

cAMP signaling pathway

ko04024

21 (3.14%)

0.00676

Environmental Information Processing

Signal transduction

Glycolysis/Gluconeogenesis

ko00010

11 (1.65%)

0.0107

Metabolism

Carbohydrate metabolism

Protein digestion and absorption

ko04974

21 (3.14%)

0.0311

Organismal Systems

Digestive system

Cysteine and methionine metabolism

ko00270

8 (1.2%)

0.0327

Metabolism

Amino acid metabolism

Amino sugar and nucleotide sugar metabolism

ko00520

12 (1.8%)

0.0412

Metabolism

Carbohydrate metabolism

  1. The Bonferroni correction method was used for multiple hypothesis test correction and FDR-corrected P < 0.05 as cut-off