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Fig. 2 | BMC Evolutionary Biology

Fig. 2

From: Inferring Methionine Sulfoxidation and serine Phosphorylation crosstalk from Phylogenetic analyses

Fig. 2

Comparing models of evolution for the S218-M222 PTM site pair on eIF2α. The compared models were one assuming independent evolution of both PTM sites (null model), and an other assuming coevolution (alternative model). The likelihood value under a given model measures the fit of that model to data. Hence, the two models can be compared by comparing their respective likelihood values. The computed LRT statistic value for the independent versus dependent evolution was 15.9 (arrow). Since in our case both models were nested (see Methods), the probability distribution of the LRT statistic, assuming that the null model is true, can be approximated by a χ2 distribution with four degree of freedom (black continuous curve). In this way, the null model (independent evolution of both sites) could be rejected with a p-value of 0.003. The same conclusion was reached when the distribution of the LRT statistic was derived by Monte Carlo simulation (histogram bars)

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