Fig. 7

Specificity determining positions discriminating each pair of duplicated visual arrestins in teleosts. Amino acid frequency logos are shown for SAGa vs. SAGb (a, b) and for ARR3a vs. ARR3b (c, d) in teleosts. Positions that are known to directly confer a specific functionality in mammalian arrestins are marked by arrows. Of these, some mutations change the charge of the respective residue (marked with *). Positions identified by SDP analysis are highlighted by black boxes. As receptor specificity is mediated by a rather big interface, only the SDPs are shown that are known to be involved in receptor binding and their first and second order neighbors. Additional positions that show differences in both groups (manually identified) and might be associated with the respective function are highlighted with a dotted box. See [2] (pos. 10, 77, 81/76, 82, 319/313), [33] (pos. 195, 254/248), [23] (pos. 52, 54/49, 265), [17] (pos. 157, 273), [19] (pos. 90/85, 244, 267, 246/240, 261/255) for references of receptor binding residues, [19] (pos. 171/165, 175/169) for phosphate binding and [118] (pos. 163/157, 166/160, 167/161) for IP6 binding residues. The numbering refers to the position numbers in bovine SAG and ARR3, respectively. Results are also summarized in Additional file 6. The figure was created with Weblogo [116]. Ins - Insertion in comparison to reference