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Fig. 5 | BMC Evolutionary Biology

Fig. 5

From: Uncovering missing pieces: duplication and deletion history of arrestins in deuterostomes

Fig. 5

Specificity determining positions discriminating between sea urchin ARR0.1 and ARR0s including ARR0.2 from sea urchins. Amino acid frequency logos are shown for ARR0 and ARR0.1 of sea urchins ordered by functionality of motifs known from studies in vertebrate arrestins (ad). Positions that are known to directly confer the respective functionality are marked by arrows. Some mutations change the charge of the respective residue (marked with *). Positions identified by SDP analysis are highlighted by black boxes. As receptor specificity is mediated by a rather big interface, only the SDPs are shown that are known to be involved in receptor binding and their direct neighbors. An additional position that shows differences in both groups (manually identified) and is associated with the respective function is highlighted by a dotted box. The numbering of the positions refers to bovine ARRB1. See the following references: [2] (pos. 14), [32] (pos. 67, 78, 80, 82 in finger loop region), [17] (pos. 154, 233), [19] (pos. 242), [23] (pos. 245, 247, 248, 249) for receptor binding residues, [34] (pos. 157, 160, 161, 165, 232, 236, 250, 324, 326) for IP6 binding residues, [19] (pos. 165, 169) for phosphate sensing and [35] (pos. 385, 388, 391, 393, 395) for AP-2 binding residues. Results are also summarized in Additional file 6. The figure was created with Weblogo [116]

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