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Table 3 Tyrosine phosphoryation of Irs proteins

From: Evolution of the vertebrate insulin receptor substrate (Irs) gene family

 

Irs1

Irs2

Irs3

Irs4

Species

Ya

pYb

Y

pY

Y

pY

Y

pY

Mouse

34

20

36

21

17

10

29

13

Rat

35

22

36

21

18

13

30

17

Golden hamster

34

20

37

20

14

8

31

15

Prairie vole

34

21

37

20

17

11

34

13

Prarie deer mouse

34

20

37

20

18

12

27

15

Coqurel’s sifka

34

20

38

21

16

7

33

15

Mouse lemur

34

20

38

20

16

8

31

16

Mouflon sheep

34

19

38

20

14

8

30

15

Killer whale

33

20

38

21

17

8

28

15

Xenopus tropicalis

32

22

31

17

25

16

39

24

Average

33.8

20.4

36.6

20.1

17.2

10.1

31.2

15.8

Conservedc

27

16

25

13

10

5

17

9

  1. aNumber of tyrosine residues in the sequence
  2. bNumber of tyrosine residues predicted to be phosphorylated
  3. cNumber of residues conserved across the 10 sequences