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Fig. 2 | BMC Evolutionary Biology

Fig. 2

From: Human MFAP1 is a cryptic ortholog of the Saccharomyces cerevisiae Spp381 splicing factor

Fig. 2

Results of MFAP1 ortholog searches focused on the fungal kingdom. The protein sequence of Homo sapiens MFAP1 (UniProt ID: P55081) (hs) was used as template in BLAST searches against 103 fungi that represent the fungal tree of life as published by Medina et al. [42]. Seven MFAP1 orthologs identified in the Saccharomycotina subphylum, i.e. MFAP1 orthologs of Y. lipolytica (UniProt ID: Q6CA21), P. pastoris (UniProt ID: A0A1B2J9D1), D. hansenii (UniProt ID: Q6BII8), C. albicans (UniProt ID: C4YG44), K. lactis (UniProt ID: Q6CJ60), C. glabrata (UniProt ID: Q6FU95) and S. cerevisiae Spp381 (UniProt ID: P38282), were then used as query sequences in further individual BLAST searches against the 25 Saccharomycotina species, including 14 Saccharomycetaceae species, that are part of the 103 fungal species. The identification of an ortholog within a species is indicated by black boxes (high confidence) or grey boxes (medium confidence). The fraction of the tree comprising Non-Saccharomycetaceae Saccharomycotina nodes is colored in orange; the tree fraction comprising Saccharomycetaceae nodes is colored in red. See Additional file 2 for raw data of BLAST searches

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