Implications of hepatitis C virus subtype 1a migration patterns for virus genetic sequencing policies in Italy

Table 1 Overview of the complete dataset used in this study

Geographic origin	HCV1a dataset (n, % dataset)	Q80K (n, % country)	Sample time span
Italy^a	280 (45.9)	52 (18.6)	2004-2015
US^b	145 (23.8)	58 (24.6)^c	1989-2008
Germany	67 (11.0)	19 (28.4)	2003-2013
Switzerland	46 (4.5)	6 (13.0)	2002-2006
Belgium	25 (4.1)	8 (32.0)	2007-2013
Thailand	19 (3.1)	3 (15.8)	2007-2010
France	13 (2.1)	/	2007-2011
Spain	5 (0.8)	/	2001-2002
UK	4 (0.7)	/	2008-2010
Brazil	2 (0.3)	/	2001-2003
Australia	2 (0.3)	/	2007
China	1 (0.2)	/	2009
Japan	1 (0.2)	/	2009
Total	610	146 (23.9)	1989-2015

The absolute and relative contribution of each country, the number of Q80K variants and their share by country, and the time span of the samples included per country, are detailed. ^a183 (63%) of the Italian sequences have not been published before. ^bTo assess the proportion of Q80K strains, the 91 taxa from the removed cluster were taken into account (see Methods). ^cSince the Q80K prevalence in the US was lower than expected, it was recalculated taking strains without sampling time information into account, resulting into a prevalence of 57.5%

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