Fig. 1

A homology model of the 3D structure of the B. manjavacas estrogen-like receptor LBD (yellow). a Superimposition of the rotifer (model) and human (X-ray) ER LBDs (pink). The model suggests that the structure of the binding pocket is conserved between human and rotifer. b Close up view of the rotifer ER LBD ligand binding site occupied by estradiol. The amino acids that form the ligand binding site are indicated. Hydrogen bonds are dashed black lines. van der Waals contacts are diffuse red lines. The 3D structure of the human ER LBD was used as a template to construct the 3D model of the rotifer estrogen-like receptor LBD