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Table 3 Annotation of the ±10 genomic neighborhood of pabB from B. subtilis

From: Assessing in silico the recruitment and functional spectrum of bacterial enzymes from secondary metabolism

BGC000309; SM* bsu:BSU31990 Isochorismate synthase DhbC (EC 5.4.4.2) ↔ PM bsu:BSU00740 PabB; E-value 5.0E-26

E_PM

K_SM

KEGG Annotation

Pathways in ±10/±2 Nh

P

 

bsu:BSU00640 spoIIE; stage II sporulation protein E (EC 3.1.3.16)

6/3 bsu00790 Folate biosynthesis

2/1 bsu01110 Biosynthesis of secondary metabolites

1/1 bsu01130 Biosynthesis of antibiotics

1/1 bsu00270 Cysteine and methionine metabolism

1/1 bsu00920 Sulfur metabolism

1/0 bsu00970 Aminoacyl-tRNA biosynthesis

1/0 bsu01200 Carbon metabolism

1/0 bsu00770 Pantothenate and CoA biosynthesis

1/0 bsu00230 Purine metabolism

1/1 bsu01230 Biosynthesis of amino acids

  

bsu:BSU00650 yabS; hypothetical protein; K07114 Ca-activated chloride channel homolog

P

 

bsu:BSU00660 yabT; serine/threonine protein kinase (EC 2.7.11.1)

P

 

bsu:BSU00670 tilS; tRNA(ile)-lysidine synthase; K04075 tRNA(Ile)-lysidine synthase[EC 6.3.4.19]

P

S

bsu:BSU00680 hprT; hypoxanthine-guanine phosphoribosyltransferase (EC 2.4.2.8)

  

bsu:BSU00690 ftsH; ATP-dependent zinc metalloprotease FtsH (EC 3.4.24

P

 

bsu:BSU00700 coaX; type III pantothenate kinase (EC 2.7.1.33)

  

bsu:BSU00710 hslO; 33 kDa chaperonin; K04083 molecular chaperone Hsp33

  

bsu:BSU00720 yacD; peptidyl-prolyl cis-trans isomerase

P

S

bsu:BSU00730 cysK; cysteine synthase (EC 2.5.1.47)

P

 

bsu:BSU00740 pabB; para-aminobenzoate synthase component I (EC 2.6.1.85)

P

 

bsu:BSU00750 pabA; para-aminobenzoate/anthranilate synthase component II (EC 2.6.1.85)

P

 

bsu:BSU00760 pabC; aminodeoxychorismate lyase (EC 4.1.3.38

P

 

bsu:BSU00770 sul; dihydropteroate synthase (EC 2.5.1.15

P

 

bsu:BSU00780 folB; dihydroneopterin aldolase (EC 4.1.2.25

P

 

bsu:BSU00790 folK; 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase

  

bsu:BSU00800 yazB; XRE family transcriptional regulator

  

bsu:BSU00810 dusB; tRNA-dihydrouridine synthase (EC 1.-.-.-)

P

 

bsu:BSU00820 lysS; lysine--tRNA ligase

  

bsu:BSU00830 ctsR; transcriptional regulator CtsR

  

bsu:BSU00840 mcsA; hypothetical protein; K19411 protein arginine kinase activator

  1. The first line gives the name of the MIBiG cluster containing the considered SM* enzyme, the annotation of the SM* and the related putative PM enzyme from the same genome, and the BLAST E-value resulting from the comparison of the corresponding two protein sequences
  2. The following lines characterize the ±10 genomic neighbourhood of the putative PM enzyme. A “P” in column “E_PM” indicates that this enzyme function, i. e. EC number, occurs in enzymes PM* and an “S” in column “K_SM” indicates that KEGG assigned this enzyme function to the pathway “Biosynthesis of secondary metabolites”. The column named “KEGG Annotation” lists KEGG-ID, function and EC number of the gene products. The column named “Pathways in ±10/±2 Nh” lists the number of genes from the corresponding two neighborhoods of the putative PM enzyme that belong to the listed KEGG pathways. For this table, the gene annotations taken from the respective html-page were shortened for the sake of brevity
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BMC Ecology and Evolution

ISSN: 2730-7182

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