Phylogenetic analysis of ionotropic L-glutamate receptor genes in the Bilateria, with special notes on Aplysia californica

Table 1 Placement of Protostomia iGluR into subtypes based on phylogenies

Species	AMPA	Kainate	NMDA	Orphans
Aplysia californica	GluR1 GluR2 GluR3 GluR4 GluR5 GluR8	GluR7 KA2	Grin1 Grin2	KA1 GluR6
Caenorhabditis elegans	GluR1 GluR2	none	Grin1 Grin2	GluR3 GluR4a GluR5 GluR6 GluR7
Drosophila melanogaster	GluR1A GluR1B GluR1C	GluR2D GluRIIE	Grin1 Grin2	GluRIIA GluRIIB GluRIIC
Daphnia magna	none	GRIK1	Grin1 GluR1 Grin2 Grin3	GRIK2
Limulus polyphemus	GluR1	GRIK2 GRIK3	Grin1 Grin2 Grin3	GRIK1 GluR4 GluR2
Lingula anatina	GluR2 GluR4	GRIK2	Grin1 Grin2	GluR1
Octopus bimaculoides	GluR	none	Grin1 Grin3	GRIK2
Priapulus caudatus	GluR3 GluR4	none	Grin1 Grin2 Grin3	GRIK3 GluR1 GluR2 GRIK4
Tribolium castaneum	none	GRIK1 GluR1	Grin1 Grin2	GRIK2 GRIK3 GRIK5 GluR2

iGluR genes in each protostome species were categorized into subtypes based on their phylogenetic relationship with chordate iGluR genes. Many protostome iGluR genes do not have a clear relationship with chordate subtypes and are thus identified as orphan receptors. Protostome orphan receptors are divergent from chordate genes and thus unlikely to perform the same subtype specific functions

ISSN: 2730-7182