Structure and evolution of the filaggrin gene repeated region in primates

Table 2 Positively selected codons and branches of the filaggrin gene in five primate species

Site-based test
Models compared	P value	Positively selected codons
M1a vs M2a^a	1.40 E-42	21, 24, 26, 75, 99, 110, 135, 144, 150, 157, 178, 187, 190, 191, 224, 226, 228, 231, 252, 268, 269, 305, 323
M7 vs M8^a	1.05 E-50	4, 21, 24, 26, 75, 99, 110, 127, 135, 144, 150, 152, 157, 178, 187, 190, 191, 205, 224, 226, 228, 231, 245, 252, 268, 269, 305, 309, 320, 323
Branch-based test
Models compared	P value
M0 vs free ratio^b	0.13	–
Branch-site test
M0N0 vs M2N2^c	P value	Positively selected codons
Crab-eating macaque cluster	1.27 E-60	No sites
Orangutan cluster	2.54	26, 119, 160, 177, 179, 207, 250, 284
Gorilla/chimpanzee/human cluster	1.80 E-93	24, 26, 78, 99, 110, 114, 134, 135, 144, 150, 152, 157, 169, 178, 187, 191, 224, 228, 231, 245, 268, 320, 323

^aThe site-based test compared the M1a (nearly neutral) and M2a (positive selection) models and the M7 (Beta) and M8 (Beta and ω) models
^bThe branch-based test compared the free ratio (or independent ω per branch) model with the one-ratio null (or one ω for all branches) model (M0)
^cThe branch-site test was used to detect positively selected codons on a specific branch

ISSN: 2730-7182