Table 3 Overrepresented biological processes associated with human genes with promoter models found in mammalian HAP1 gene promoters
GO-Term ID | GO-Term | Observed # genes | Expected # genes | Fold enrichment | p-value | Gene Symbols (MAX-CDX1/2-TBP model only) |
|---|---|---|---|---|---|---|
Promoter model: CDX1/2-TBP CDX1(neg)-0 bp-CDX2(neg)-2 bp-TBP(pos) | ||||||
GO:0007156 | Homophilic cell adhesion via plasma membrane adhesion molecules | 62 | 32.9 | 1.9 | 5.0E-08 | |
GO:0005513 | Detection of calcium ion | 12 | 3.2 | 3.7 | 1.2E-06 | |
GO:0007059 | Chromosome segregation | 72 | 46.0 | 1.6 | 2.0E-05 | |
GO:0006200 | ATP catabolic process | 115 | 81.9 | 1.4 | 3.1E-05 | |
GO:0007018 | Microtubule-based movement | 69 | 44.2 | 1.6 | 3.1E-05 | |
GO:1902115 | Regulation of organelle assembly | 35 | 19.1 | 1.8 | 7.8E-05 | |
GO:0048384 | Retinoic acid receptor signaling pathway | 24 | 11.5 | 2.1 | 9.1E-05 | |
GO:0019722 | Calcium-mediated signaling | 45 | 26.7 | 1.7 | 9.4E-05 | |
GO:1900544 | Positive regulation of purine nucleotide metabolic process | 170 | 134.1 | 1.3 | 2.7E-04 | |
GO:0006793 | Phosphorus metabolic process | 909 | 831.9 | 1.1 | 3.3E-04 | |
GO:0051301 | Cell division | 206 | 167.2 | 1.2 | 3.6E-04 | |
GO:0071840 | Cellular component organization or biogenesis | 1256 | 1173.0 | 1.1 | 4.8E-04 | |
GO:0009056 | Catabolic process | 740 | 671.2 | 1.1 | 5.0E-04 | |
GO:0022402 | Cell cycle process | 315 | 268.4 | 1.2 | 5.3E-04 | |
GO:0007399 | Nervous system development | 502 | 446.9 | 1.1 | 9.5E-04 | |
Promoter model: MAX-CDX1/2-TBP MAX(pos/neg)-15 to 60 bp-CDX1(neg)-0 bp-CDX2(neg)-2 bp-TBP(pos) | ||||||
GO:0048387 | Negative regulation of retinoic acid receptor signaling pathway | 6 | 0.08 | 75.0 | 1.0E-10 | PRAMEF5, PRAMEF6, PRAMEF9, PRAMEF15, PRAMEF20, PRAMEF25 |
GO:0043066 | Negative regulation of apoptotic process | 10 | 1.97 | 5.1 | 1.8E-05 | PRDX2, CITED1, KIAA1324, PRELID1, PRAMEF5, PRAMEF6, PRAMEF9, PRAMEF15, PRAMEF20, PRAMEF25 |
GO:0030522 | Intracellular receptor signaling pathway | 6 | 0.71 | 8.5 | 6.7E-05 | PRAMEF5, PRAMEF6, PRAMEF9, PRAMEF15, PRAMEF20, PRAMEF25 |
GO:0050793 | Regulation of developmental process | 14 | 4.57 | 3.1 | 8.2E-05 | SHROOM3, HAP1, NEFM, TNFSF9, CITED1, PRELID1, GDF11, FADS1, PRAMEF5, PRAMEF6, PRAMEF9, PRAMEF15, PRAMEF20, PRAMEF25 |
GO:0008284 | Positive regulation of cell proliferation | 9 | 1.91 | 4.7 | 9.1E-05 | TNFSF9, ADRA2A, TFF2, PRAMEF5, PRAMEF6, PRAMEF9, PRAMEF15, PRAMEF20, PRAMEF25 |
GO:1901019 | Regulation of calcium ion transmembrane transporter activity | 3 | 0.12 | 25.0 | 2.4E-04 | HAP1, ADRA2A, STIM1 |
GO:0005513 | Detection of calcium ion | 2 | 0.04 | 50.0 | 5.6E-04 | KCNIP1, STIM1 |