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Table 1 Genes with an excess of squares in their giant component

From: Parallel or convergent evolution in human population genomic data revealed by genotype networks

Gene name

Previous evidence of positive selection

Number of squares in the giant component

TTN

None

11

MKI67

None

14

OBSCN

None

15

PKD1L2

None

18

MUC16

None

22

MUC17

None

26

IGFN1

[54]

31

GPR98

[54]

31

PRUNE2

None

35

SYNE2

None

41

AHNAK2

None

41

HLA-DPB1

[62, 78–81]

48

ALPK2

None

50

HLA-C

[62, 78–81]

50

FLG

None

54

PRAMEF2

[54]

55

HRNR

None

55

MUC5B

None

58

PCLO

[54]

67

HLA-A

[62, 78–81]

67

MUC12

None

71

LAMA5

[54]

76

CYP2A7

[82]

76

HLA-B

[62, 78–81]

76

POTED

None

80

NEB

None

96

MUC4

None

121

PKD1L1

None

160

FBN3

[54]

197

DCHS2

None

205

FRAS1

[54]

269

PLIN4

None

298

EYS

None

316

FCGBP

[54]

350

TG

None

365

USH2A

[54]

475

LILRB3

None

475

LILRA6

None

482

DNAH17

[54]

494

HLA-DRB1

[55, 62, 78–81]

507

DNAH5

[54]

602

DNAH11

None

1043

  1. The number of squares in these genes cannot be explained by random homoplasy or mutational constraints. The middle column cites studies that provide evidence for positive selection, wherever such evidence is available. After FDR correction, the p-value of the statistical test comparing the actual number of cycles against that in 1,000 randomized networks (with random mutations and mutational constraints) is 0.087 for all genes