Skip to main content

Table 1 Summary of conservation of S. cerevisiae prion and PAF proteins in taxonomically defined sets of species*

From: Emergence and evolution of yeast prion and prion-like proteins

Conservation level** Has ortholog Has ortholog and N/Q-rich domain Has ortholog and PLAAC prediction Has ortholog and PAPA prediction Has ortholog and PrionW prediction
Known Prions
 within Saccharomycetes 11/11 10 10 10 8
 within Ascomycota beyond Saccharomycetes 9 6 6 5 2
 beyond Ascomycota 9 6 6 5 2
Total set of PAFs
 within Saccharomycetes 27/27 26 26 26 21
 within Ascomycota beyond Saccharomycetes 20** 15 12 11 3
 beyond Ascomycota 18** 13 11 9 3
  1. *This table shows the fraction of the lists of prions and PAFs that are conserved in the taxonomic groups studied in this work. To be conserved ‘within Saccharomycetes’, a S. cerevisiae prion or PAF has to be found in any other Saccharomycetes species. To be conserved ‘within Ascomycota beyond Saccharomycetes’, a prion/PAF has to be found in any other Ascomycota species beyond the Saccharomycetes, and likewise for ‘beyond Ascomycota’. The columns denote the different cases simply an ortholog of the prion/PAF is detected, then an ortholog with an N/Q-rich domain, then an ortholog with a prion domain predicted by the PLAAC, PAPA or PrionW algorithms. This table includes the non-N/Q-rich prion former Mod5p
  2. **One classed as within Saccharomycetes only, has horizontal transfer (HT) to non-Saccharomycetes detected in the evolutionary tree. The prion-like domain in this cases post-dates the HT