Genomic signatures of domestication on neurogenetic genes in Drosophila melanogaster

Stanley, Craig E.; Kulathinal, Rob J.

doi:10.1186/s12862-015-0580-1

BMC Ecology and Evolution

Table 1 Enriched gene ontologies (GO) on extended haplotype block outliers for two categories of differentiated SNPs: unique among laboratory strains (lab-specific) or higher in allele frequency in the lab (Fst*_lab>wild)

From: Genomic signatures of domestication on neurogenetic genes in Drosophila melanogaster

SNP Type	GO: Biological Process	GO: ID	# of Genes in GO^a	**P-value	Count
Lab-specific	regulation of cellular component size	32535	305	0.028412	8
Lab-specific	regulation of biological quality	65008	1994	0.038348	23
Lab-specific	generation of neurons	48699	992	0.039188	22
Lab-specific	nervous system development	7399	1744	0.040839	32
Lab-specific	neurogenesis	22008	1525	0.041256	30
Lab-specific	regulation of anatomical structure size	90066	374	0.042371	10
Lab-specific	regulation of cell size	8361	89	0.042507	6
Lab-specific	cellular component organization	16043	5855	0.042708	43
Lab-specific	proboscis extension reflex	7637	9	0.043535	3
Lab-specific	reflex	60004	9	0.043535	3
Lab-specific	cell differentiation	30154	2770	0.043641	41
Lab-specific	regulation of cell morphogenesis	22604	184	0.044224	9
Lab-specific	axon development	61564	341	0.047764	12
Lab-specific	behavioral response to nutrient	51780	10	0.048507	3
Fst*_lab>wild	motor neuron axon guidance	8045	62	0.007739	9
Fst*_lab>wild	system development	48731	2850	0.00912	88
Fst*_lab>wild	post-embryonic organ development	48569	583	0.009155	29
Fst*_lab>wild	multicellular organismal development	7275	3977	0.009225	106
Fst*_lab>wild	biological regulation	65007	13920	0.009452	112
Fst*_lab>wild	single-organism cellular process	44763	23874	0.014023	162
Fst*_lab>wild	regulation of biological process	50789	13269	0.015888	106
Fst*_lab>wild	regulation of cellular process	50794	12824	0.023125	96
Fst*_lab>wild	single-multicellular organism process	44707	5981	0.024058	118
Fst*_lab>wild	post-embryonic appendage morphogenesis	35120	452	0.026085	24
Fst*_lab>wild	appendage development	48736	470	0.026896	24

^aNumber of genes from Gene Ontology (Biological Process) from FlyBase FB2015_05
**P-value calculated using Benjamini-Hochberg correction
Gene ontologies within each SNP type are ranked by P-value. No significant gene ontology class was found for haplotypes classified for significantly differentiated SNPs in which the derived SNP is found in lower frequency in the wild (i.e., Fst*_wild>lab)

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ISSN: 2730-7182

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