Fig. 5

Phylogenomic analyses of the MACITs. COL13A1, COL23A1 and COL25A1 are located in paralogous regions of the human (a), chicken (b), and freshwater pufferfish (c), genomes. In a-c, each stick diagram represents the region of the chromosome in the vicinity of the relevant MACIT gene and each horizontal line represents a gene; for simplicity of presentation, only the conserved syntenic genes have been included. Numbers above and below each diagram refer to the start and end positions of the first and last genes presented, respectively, on the chromosome in bases. In (c), T. nigroviridis COL25A1 is unmapped in the genome, but is located within the same two over-lapping scaffolds as two of the genes that are syntenic in human and chicken. d, Phylogenetic relationships of MACIT proteins. Bootstrap values above 0.95 are taken to indicate stability of a branchpoint and are shown for the major nodes. Scale bar indicates substitutions/site. Species code names in (d) are as in Table 1