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Table 2 Haplotype frequencies and molecular diversity of the six Sahelian samples in a 1,396 bp sequence encompassing the NAT2 coding exon

From: Variation in NAT2 acetylation phenotypes is associated with differences in food-producing subsistence modes and ecoregions in Africa

  

Population1

 

Haplotype

Acetylation activity2

FBAN

FTIN

FADE

FBON

DAZ

KANE

Total

NAT2*4

fast

2

4

6

8

7

2

29

NAT2*4a

fast

     

1

1

NAT2*12A

fast

6

5

 

4

11

6

32

NAT2*13A

fast

11

10

8

7

2

2

40

NAT2*5A

slow

 

1

 

1

 

3

5

NAT2*5B

slow

39

46

42

47

28

40

242

NAT2*5Ba 3

slow

  

2

1

 

1

4

NAT2*5C

slow

3

4

6

2

1

3

19

NAT2*6A

slow

32

17

20

23

23

25

140

NAT2*6Aa 3

slow

    

1

 

1

NAT2*6C

slow

   

1

  

1

NAT2*7B

slow

 

1

 

2

2

2

7

NAT2*14A

slow

2

4

7

 

1

 

14

NAT2*14B

slow

3

5

2

2

1

5

18

NAT2*14Ba 3

slow

  

1

   

1

NAT2*6F

unknown

 

1

    

1

NAT2*6O

unknown

    

1

1

2

NAT2*12H

unknown

  

2

1

4

7

14

NAT2*12N 4

unknown

 

1

    

1

NAT2*13D 4

unknown

   

1

  

1

NAT2*14K 4

unknown

 

1

    

1

Total (2N chromosomes)

98

100

96

100

82

98

574

Number of haplotypes (k)

8

13

10

13

12

13

 

Number of segregating sites (S)

6

9

9

10

10

11

 

Gene diversity (expected heterozygosity, h)

0.72

0.75

0.75

0.72

0.78

0.76

 

Nucleotide diversity (π) x 10−3

1.81

1.79

1.85

1.78

1.83

1.93

 

Tajima’s D (P-value)5

2.65 (0.994)

1.09 (0.875)

1.18 (0.891)

0.73 (0.801)

0.72 (0.799)

0.68 (0.875)

 
  1. 1Population codes as in Table 1
  2. 2Reported activity in the official NAT2 gene nomenclature (nat.mbg.duth.gr)
  3. 3Small caps alphabetical suffixes were added to the names of haplotypes that differ from known haplotypes in the flanking region of the NAT2 coding exon (see text)
  4. 4New haplotypes submitted to the official NAT2 gene nomenclature and included in it (see text)
  5. 5 P-value associated with Tajima’s D test for departure from selective neutrality: it is given as the proportion of random D values generated under the neutral equilibrium model that are smaller than, or equal to the observed value. The sole significant result is shown in bold; it corresponds to a type I error rate of 0.006, and it remains significant after Bonferroni correction for multiple testing
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BMC Ecology and Evolution

ISSN: 2730-7182

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