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Table 2 Haplotype frequencies and molecular diversity of the six Sahelian samples in a 1,396 bp sequence encompassing the NAT2 coding exon

From: Variation in NAT2 acetylation phenotypes is associated with differences in food-producing subsistence modes and ecoregions in Africa

   Population1  
Haplotype Acetylation activity2 FBAN FTIN FADE FBON DAZ KANE Total
NAT2*4 fast 2 4 6 8 7 2 29
NAT2*4a fast       1 1
NAT2*12A fast 6 5   4 11 6 32
NAT2*13A fast 11 10 8 7 2 2 40
NAT2*5A slow   1   1   3 5
NAT2*5B slow 39 46 42 47 28 40 242
NAT2*5Ba 3 slow    2 1   1 4
NAT2*5C slow 3 4 6 2 1 3 19
NAT2*6A slow 32 17 20 23 23 25 140
NAT2*6Aa 3 slow      1   1
NAT2*6C slow     1    1
NAT2*7B slow   1   2 2 2 7
NAT2*14A slow 2 4 7   1   14
NAT2*14B slow 3 5 2 2 1 5 18
NAT2*14Ba 3 slow    1     1
NAT2*6F unknown   1      1
NAT2*6O unknown      1 1 2
NAT2*12H unknown    2 1 4 7 14
NAT2*12N 4 unknown   1      1
NAT2*13D 4 unknown     1    1
NAT2*14K 4 unknown   1      1
Total (2N chromosomes) 98 100 96 100 82 98 574
Number of haplotypes (k) 8 13 10 13 12 13  
Number of segregating sites (S) 6 9 9 10 10 11  
Gene diversity (expected heterozygosity, h) 0.72 0.75 0.75 0.72 0.78 0.76  
Nucleotide diversity (π) x 10−3 1.81 1.79 1.85 1.78 1.83 1.93  
Tajima’s D (P-value)5 2.65 (0.994) 1.09 (0.875) 1.18 (0.891) 0.73 (0.801) 0.72 (0.799) 0.68 (0.875)  
  1. 1Population codes as in Table 1
  2. 2Reported activity in the official NAT2 gene nomenclature (nat.mbg.duth.gr)
  3. 3Small caps alphabetical suffixes were added to the names of haplotypes that differ from known haplotypes in the flanking region of the NAT2 coding exon (see text)
  4. 4New haplotypes submitted to the official NAT2 gene nomenclature and included in it (see text)
  5. 5 P-value associated with Tajima’s D test for departure from selective neutrality: it is given as the proportion of random D values generated under the neutral equilibrium model that are smaller than, or equal to the observed value. The sole significant result is shown in bold; it corresponds to a type I error rate of 0.006, and it remains significant after Bonferroni correction for multiple testing