Fig. 3
From: Characterizing selective pressures on the pathway for de novo biosynthesis of pyrimidines in yeast
Negative correlation between protein evolutionary rate ratios and kinetic pathway sensitivity. With the exception of URA2, each point represents an enzyme in the pathway, for which we have calculated evolutionary rate ratio dN/dS and the geometric mean sensitivity of steady-state pathway flux to kinetic parameters of that enzyme. For URA2, we separately analyzed the domains corresponding to the two enzymatic activities it performs