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Fig. 4 | BMC Evolutionary Biology

Fig. 4

From: Tex19 and Sectm1 concordant molecular phylogenies support co-evolution of both eutherian-specific genes

Fig. 4

Sectm1 protein organization. a MACS schema. Colored cylinders represent conserved regions, e.g., region A is the Ig-like domain, while thin lines stand for variable regions. Cysteines are depicted as red dots while any other residues are shown in black. The orange rectangle symbolizes a SP. The violet rectangle delineates a TM. The open blue rectangle shows the position of the G113XYXWXLXGXQ123 highly conserved motif. Arrows indicate 2 invariant cysteines. Amino-acid offsets refer to the human sequence, i.e., [RefSeq:NP_002995]. Haplorrhini sequences were clustered at the top of the alignment. b Highly conserved G113XYXWXLXGXQ123 motif logo; (c) Classical Ig domain [PDB:3SOB] used for homology modelling showing a disulfide bridge (red) between beta-sheets. d 3D model of Sectm1 Ig-like domain, the atypical disulfide bond that is predicted to join both invariant cysteines is depicted in red

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