Table 1 The 26 RNAi knockdown phenotypes surveyed in this study. Bolded lines indicate phenotypes that are enriched for proteins that significantly deviate from the genome average in their direction of selection (DoS) statistic
From: The effects of natural selection across molecular pathways in Drosophila melanogaster
Phenotype category | RNAi knockdown phenotype | n a | DoS |
|---|---|---|---|
Regulation of intracellular signal transduction | Akt-TOR signaling decrease | 24 | –0.019 |
|  | Akt-TOR signaling increase | 22 | –0.118 |
|  | Hippo signaling decrease | 99 | –0.005 |
|  | Hippo signaling increase | 54 | –0.021 |
| Â | JAK/STAT signaling decrease | 10 | 0.044 |
|  | JAK/STAT signaling increase | 6 | –0.075 |
|  | RTK-Ras-ERK signaling decrease | 113 | –0.045 |
|  | RTK-Ras-ERK signaling increase | 55 | –0.018 |
Cell surface receptor signaling pathway | Hedgehog signaling decrease | 48 | 0.043 b |
| Â | Hedgehog signaling increase | 30 | 0.006 |
|  | Notch signaling decrease | 16 | –0.018 |
|  | Notch signaling increase | 18 | –0.107 |
| Â | Toll signaling decrease | 17 | 0.028 |
| Â | Toll signaling increase | 11 | 0.005 |
|  | Wnt signaling activity | 90 | –0.043 |
Regulation of transposon integration | Blood TE activity increase | 43 | 0.011 |
|  | Burdock TE activity increase | 15 | –0.080 |
| Â | HeTA TE activity increase | 38 | 0.024 |
|  | TAHRE TE activity increase | 41 | –0.002 |
Innate immune response | Influenza replication decrease | 18 | –0.047 |
| Â | Innate immunity | 13 | 0.097 b |
|  | M. fortuitum infection decrease | 27 | –0.111 |
Regulation of extent of cell growth | Cell size regulation | 5 | 0.012 |
|  | Cell growth and viability | 96 | –0.014 |
Regulation of circadian rhythm | CRY degradation | 93 | 0.006 |
Hypoxia-inducible factor-1alpha signaling pathway | Hypoxia induced transcription | 49 | –0.025 |
N/A | Lethals | 2853 | –0.031 |
N/A | Whole-genome | 11148 | –0.035 |