Fig. 3

Crystal structure of the entire respiratory complex I at 3.3 Å (PDB: 4HEA) from Thermus thermophiles front view (a). Mitochondrial gene encoded subunits include Nqo8 (MT-ND1) (orange) (b), Nqo14 (MT-ND2) (yellow), Nqo7 (MT-ND3) (red), Nqo13 (MT-ND4) (blue) (d), Nqo11 (MT-ND4L) (white), Nqo12 (MT-ND5) (magenta) (c), and Nqo10 (MT-ND6) (green) subunits. Amino acid sites in cyan are those with evidence of positive selection in this study. Structure in gray indicates the nuclear-gene encoded hydrophilic domain