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Fig. 5 | BMC Evolutionary Biology

Fig. 5

From: Evolutionary analysis of selective constraints identifies ameloblastin (AMBN) as a potential candidate for amelogenesis imperfecta

Fig. 5

a. Estimation of the codon conservation index along the mammalian AMBN sequences. Positions 1 to 447 refer to the human sequence. Low evolutionary rates i.e., values close to 1, indicate the conserved / important positions, while high evolutionary rates i.e., values close to 0, indicate more variable positions. b Amino acid sequence of human AMBN. Human AMBN is composed of 447 residues when including the 26 residues of the putative leader peptide encoded by exons 1 and 2 (numbers above the residues); otherwise, 421 amino acids constitute the protein (numbers below the residues). Conserved positions are indicated either on black background (unchanged) or on gray background (only replaced with a residue having the same chemical property); variable positions are on white background. Various remarkable domains and remarkable residues are figured in color. The arrow points to the cleavage site of the signal peptide. Arrowheads point to proteolytic sites identified in porcine AMBN. The five sites under significant positive selection are indicated with an asterisk

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