Fig. 2

E2 represses the promoter activities of four MCPH genes. a Quantification of repressive activity of ASPM gene and the ASPM-1326 and ASPM-86 deletion mutants using luciferase reporter gene assay. b Quantification of repressive activity with deletion mutations of half ERE sequence at −1060, −726, −654,-525,-504 and −201 upstream of the CDK5RAP2 translation start site and CDK5RAP2 gene using luciferase reporter gene assay. c Quantification of repressive activity with deletion mutations of half ERE sequence at −1404, −754 and −632 upstream of the MCPH1 translation start site and also MCPH1 gene, using luciferase reporter gene assay. d Quantification of repressive activity with deletion mutations of half ERE sequence at −727 and −1679 upstream of the WDR62 translation start site and WDR62 gene using luciferase reporter gene assay. The HEK293T cells were transiently transfected with vector containing human ERα