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Table 2 Identified outlier loci in the AVPR1A gene that are under balancing selection and directional selection using the approaches FDIST, BayeScan and F.LK

From: Signatures of positive selection in the cis-regulatory sequences of the human oxytocin receptor (OXTR) and arginine vasopressin receptor 1a (AVPR1A) genes

 

FDIST

BayeScan

FLK

Locus

Function

H E

F ST

P

log10(BF)

q

α i

F ST

F.LK

F.LK.p.val

rs12830859

Downstream

0.2631

0.0143

0.0000

1.1382

0.0455

−1.2413

0.0271

  

rs1587098

Downstream

0.1412

0.0111

0.0000

      

rs1580705

Downstream

0.1311

0.0176

0.0008

      

rs11174805

Downstream

0.1412

0.0111

0.0000

      

rs11174806

Downstream

0.1412

0.0111

0.0000

      

rs11174807

Downstream

0.1431

0.0124

0.0000

      

rs117072097

3′UTR

0.0272

0.0041

0.0013

      

rs11174811

3′UTR

0.1467

0.0047

0.0000

1.2742

0.0336

−1.3077

0.0255

  

rs34462214

Intron

0.1549

0.0048

0.0000

1.5306*

0.0252

−1.3346

0.0248

  

rs3021529

5′UTR

0.1567

0.0057

0.0001

1.1260

0.0270

−1.2497

0.0270

  

rs3759292

Promoter

       

14.1

0.001

rs7308855

Upstream

0.1114

0.0020

0.0000

2.1158*

0.0076

−1.6966

0.0178

  
  1. The results with significance P value < 0.005 are shown for FDIST and F.LK; * the BayeScan log10(BF) > 1.5 indicating ‘very strong’ evidence (P(α ≠ .5 = 0.03 → 0.01) for selection. All SNPs except SNP rs3759292 are under balancing selection