Figure 3
From: The origin of the ADAR gene family and animal RNA editing
Possible scenarios for ADAR evolution in the metazoan ancestor. Five different scenarios of gene gain and loss events could explain the ADAR family distribution observed in sponges, ctenophores and eumetazoans, depending on whether sponges or ctenophores are the earliest-branching metazoan lineage. Filled and blank shapes represent gene (coloured squares) or ZB domain (triangles) gain and loss events, respectively. In panel v, the arrow represents the possible conversion of an ADAR1-like sequence to an ADAD-like architecture via domain loss.