Figure 5

Roles of targeted genes in membrane synthesis. Two genomic mutations were identified in the genes tktA and cdsA, which are involved in membrane synthesis from glucose metabolism. In the metabolic flow from glucose to membrane synthesis, TktA is involved in the pentose phosphate pathway to produce NADPH, which is required for fatty acid synthesis. Using fatty acids, CdsA is involved in membrane phospholipid synthesis, followed by membrane construction, which affects cell size.