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Table 2 Rough estimates of k cat values under conditions of enzyme excess

From: Empirical demonstration of environmental sensing in catalytic RNA: evolution of interpretive behavior at the origins of life

Variant O1 O2 O3 O4 O1  > O2 O1  > O3 O4  > O2 O1 > O4
CG 7.0 × 10−3 2.3 × 10−7 5.5 × 10−3 5.5 × 10−5 yes yes yes yes
PV 6.9 × 10−3 < 10−8 1.0 × 10−3 < 10−8 yes yes N.D. yes
  1. All values given in units of min−1. For the PV, yields under the O2 and O4 conditions were too small to estimate rate constants. Rank-ordering of the conditions are as follows. CG: O1 > O3 > O4 > O2; PV: O1 > O3 > O4 & O2. However, the conditions of enzyme excess are not representative of an evolutionary interpretive scenario, hence the data in Table 1 were used for this purpose. N.D. = not determined.