Figure 5

Distinct evolutionary pressures on disease classes of different origins in popular mammalian models. Comparison of the distribution of human disease gene dN/dS ratios for the 29 deviating disease classes, separated according to their age-related signature as defined in Figure 4: A) vertebrate-specific, B) early metazoan, and C) multi-stage metazoan classes, and compared across nine mammalian species relative to the expected distribution of all human disease genes from OMIM. Points indicate median dN/dS with 95% confidence intervals. Only statistically significant differences are displayed (Mann-Whitney U two-tailed test; p < 0.05, Bonferroni-corrected).