Figure 1
Distribution of human disease gene orthologs. Heat maps showing the presence (green) or absence (red) of an ortholog for a given human disease gene from OMIM (rows) within each species (columns). All 2727 human disease genes from OMIM are displayed. Major phylogenetic divergence events define the six phylostratigraphic bins indicated in the phylogenetic species tree. Rows are ordered such that disease genes first appearing in each phylostratigraphic bin (indicated by black lines) are clustered, with the corresponding percentage of the total for each cluster projected on the stacked bar on the left. Hs, Homo sapiens; Gg, Gallus gallus; Xt, Xenopus tropicalis; Dr, Danio rerio; Ci, Ciona intestinalis; Bf, Branchiostoma floridae; Sp, Strongylocentrotus purpuratus; Lg, Lottia gigantea; Ct, Capitella teleta; Hr, Helobdella robusta; Sm, Schistosoma mansoni; Pp, Pristionchus pacificus; Ce, C. elegans; Dm, D. melanogaster; Dp, Daphnia pulex; Is, Ixodes scapularis; Hm, Hydra magnipapillata; Nv, N. vectensis; Ta, T. adhaerens; Aq, A. queenslandica; Ml, M. leidyi; Mb, M. brevicollis; Co, C. owczarzaki.