Figure 2

Partial multiple sequence alignment of the deduced HIF-1α protein sequences. A) In Cyprinidae, HIF-1αA proteins were found to have a deletion (LxxLAP) in the conserved NODD domain. B) Specialized and highly specialized schizothoracine fish were found to have a mutation (LxxLAP to PxxLAP) in the conserved CODD domain of HIF-1αB. Dashes indicate that the gaps inserted for facilitated alignment. The two conserved proline hydroxylation motif LxxLAP are indicated by the dotted boxes.