Table 1 Sequence information of homologues of RIG-I, MDA5, LGP2, DICER and eIF4A in vertebrates and invertebrates

RIG-I

Human

ENSG00000107201

NM_014314

925

100/100

Xenopus

ENSXETG00000009200

945

43.6/64.2

Zebrafish

ENSDARG00000039785

628

25.9/41.3

MDA5

Human

ENSG00000115267

NM_022168

1025

100/100

Chicken

ENSGALG00000011089

XM_422031

1285

47.8/58.8

Xenopus

ENSXETG00000013176

1003

53.3/69.2

Zebrafish

ENSDARG00000018553

XM_689032

1219

34.5/52.4

Stickleback

ENSGACG00000005518

1008

47.1/64.3

Medaka

ENSORLG00000016902

987

47/65.9

Fugu

ENSTRUG00000001413

1000

44.7/63

Tetraodon

ENSTNIG00000016500

1038

42.6/63

LGP2

Human

ENSG00000108771

NM_024119

678

100/100

Chicken

ENSGALG00000023821

588

43.6/59.1

Xenopus

ENSXETG00000002302

588

46.8/61.8

Zebrafish

ENSDARG00000070935

XM_001920601

682

40.8/62.5

Stickleback

ENSGACG00000008740

681

47.2/68.9

Medaka

ENSORLG00000003825

673

47.4/66.1

Fugu

ENSTRUG00000015710

671

46.2/64.7

Tetraodon

ENSTNIG00000011713

680

47.7/65.9

DICER

Human

ENSG00000100697

NM_177438

1922

100/100

Chicken

ENSGALG00000010999

NM_001040465

1921

92.0/96.0

Xenopus

ENSXETG00000023315

422

18.9/20.6

Zebrafish

ENSDARG00000001129

XM_678382

1975

75.5/84.4

Stickleback

ENSGACG00000020134

1901

75.9/84.5

Medaka

ENSORLG00000011022

1905

76.5/85.2

Fugu

ENSTRUG00000006156

1896

75.8/84.4

Tetraodon

ENSTNIG00000005441

1915

75.8/85.0

Sea urchin DICER

XM_785801

1850

41.0/60.1

Caenorhabditis elegans DRH1

F15B10.2

NM_068617

1037

14.2/27.5

Caenorhabditis elegans DRH2

C01B10.1

956

14.4/26.1

Caenorhabditis elegans DRH3

D2005.5

NM_059760

1119

15.8/28.7

Caenorhabditis elegans DCR1

K12H4.8

NM_066360

1845

33.7/53.3

Drosophila DCR1

NM_079729

2249

32.0/50.1

Jewel wasp DICER1

XM_001605237

1917

37.3/59.5

eIF4A

Human eIF4A1

ENSG00000161960

BT019879

407

100/100

Chicken eIF4A2

NM_204549

407

90.4/96.3

Xenopus eIF4A

ENSXETG00000020123

NM_001011139

406

94.8/98.5

Zebrafish eIF4A1a

ENSDARG00000040268

NM_198366

406

89.4/96.8

Zebrafish eIF4A1b

ENSDARG00000003032

NM_201510

406

89.2/97.1

Stickleback eIF4A1

ENSGACG00000020072

406

89.7/97.3

Medaka eIF4A1

ENSORLG00000010659

405

89.7/97.3

Fugu eIF4A1

ENSTRUG00000002188

406

78.9/90.4

ENSTRUG00000017170

408

63.9/81.6

ENSTRUG00000011113

411

62.6/80.5

Tetraodon eIF4A1

ENSTNIG00000004408

292

55.6/64.9

ENSTNIG00000017079

352

60.7/73.5

ENSTNIG00000006865

384

68.1/84.3

ENSTNIG00000007405

411

69.2/87.1

ENSTNIG00000004366

316

55.4/66.8

ENSTNIG00000000303

339

47.7/64.6

Drosophila eIF4A

FBgn0001942

NM_164668

403

72.1/86.7

NM_164669

NM_057247

NM_164670

Sclerotinia sclerotiorum eIF4A

XM_001594601

398

74.7/86.5

Botryotinia fuckeliana eIF4A

XM_001561331

398

74.4/86.5

Invertebrate RIG-I like genes

Sea urchin RIG-I (LOC591972)

NW_001470282

XM_791516

960

26.4/47.8

Sea urchin RIG-I (LOC575036)

NW_001312424

XM_001176480

823

23.8/43.2

Sea urchin RIG-I (LOC767124)

NW_001297703

XM_001203626

303

11.8/19.2

Sea urchin RIG-I (LOC574972)

NW_001312424

XM_775381

968

29.3/50.3

Sea urchin RNA helicase (LOC593153)

XM_792644

996

21.4/41.0

Sea urchin RNA helicase (LOC583008)

XM_001198571

480

16.1/26.4

Sea urchin RIG-I

XM_778463

927

28.7/49.7

Sea urchin RNA helicase (LOC578749)

XM_778903

870

27.2/48.6

Sea urchin RIG-I (LOC582062)

XM_782035

209

10.7/14.5

Sea urchin RIG-I (LOC577076)

XM_777329

1051

19.9/39.7

Nematostella vectensis RIG-I/MDA5 like gene 1

XM_001636292

XP_001636342

672

26.3/41.0

Nematostella vectensis RIG-I/MDA5 like gene 2

XM_001639190

XP_001639240

689

25.5/41.7