Gene synteny comparisons between different vertebrates provide new insights into breakage and fusion events during mammalian karyotype evolution

Table 6 Numbers of evolutionary breakpoint intervals on chromosomes 1 – 22, length of the respective chromosomes and gene density.

Chromosome	Number of evolutionary breakpoint intervals per chromosome	Chromosome length (bp) ^a	Number of protein-coding genes per chromosome ^a	Gene density (genes/100 kb)	Breakpoint density (breakpoint interval/100 kb)
1	47	247,249,719	2189	8.85	0.19
2	46	242,951,149	1328	5.47	0.19
3	45	199,501,827	1112	5.57	0.23
4	21	191,273,063	797	4.17	0.11
5	42	180,857,866	903	4.99	0.23
6	28	170,899,992	1133	6.62	0.16
7	37	158,821,424	1023	6.44	0.23
8	30	146,274,826	747	5.11	0.21
9	20	140,273,252	929	6.62	0.14
10	20	135,374,737	834	6.16	0.15
11	31	134,452,384	1385	10.30	0.23
12	18	132,349,534	1080	8.16	0.14
13	9	114,142,980	361	3.16	0.08
14	11	106,368,585	669	6.29	0.10
15	16	100,338,915	641	6.39	0.16
16	12	88,827,254	925	10.41	0.13
17	31	78,774,742	1236	15.69	0.39
18	11	76,117,153	295	3.88	0.14
19	17	63,811,651	1443	22.61	0.27
20	20	62,435,964	617	9.88	0.32
21	6	46,944,323	284	6.05	0.13
22	9	49,691,432	519	10.44	0.18

a: according to the Ensembl database, version 47.36i. The gene density per chromosome was found to be correlated with the number of breakpoint intervals (r = 0.60; p = 0.0031).

ISSN: 2730-7182