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Table 5 Evolutionary breakpoint intervals 'co-localizing' with known cancer-associated genes.

From: Gene synteny comparisons between different vertebrates provide new insights into breakage and fusion events during mammalian karyotype evolution

Human chromosome

Evolutionary breakpoint interval a

Cancer-associated genes located within the respective evolutionary breakpoint interval b

Species exhibiting the corresponding evolutionary break

 

Position of the 5' boundary (Mb)

Position of the 3' boundary (Mb)

  

1

1.85

2.28

PRKCZ, SKI

MDO, GGA

2

230.76

231.4

SP100

BTA, MDO, GGA

3

184.47

184.69

MCF2L2

BTA, MDO

5

112.29

112.88

ZRSR1, MCC

MMU, CFA, MDO

6

74.03

74.19

DDX43

RNO, MMU

11

75.60

76.05

C11orf30

BTA

11

93.55

93.92

MRE11A

BTA

11

101.61

101.77

BIRC3

BTA

11

110.09

110.84

POU2AF1

GGA

12

56.26

56.62

CDK4

GGA

19

58.70

59.41

TFPT

MMU

  1. a: Evolutionary breakpoint intervals are indicated with respect to their position on the orthologous human chromosome.
  2. b: Data on cancer-associated genes were extracted from the Atlas of Genetics and Cytogenetics in Oncology and Haematology http://atlasgeneticsoncology.org.