Correlated evolution of nucleotide substitution rates and allelic variation in Mhc-DRB lineages of primates

Table 4 Correlation between different estimates of nucleotide substitution rates (N: non-synonymous, S: synonymous) of the DRB103* lineage when sampled across all available species (N = 18) and when only catarrhines are considered (N = 11).

All species, N = 18	dS, ABS	dN, non-ABS	dS, non-ABS
dN, ABS	0.561*	0.927***	0.771***
dS, ABS		0.480*	0.418†
dN, non-ABS			0.749***
Only catarrhine species, N = 11	dS, ABS	dN, non-ABS	dS, non-ABS
dN, ABS	0.673*	0.947***	0.800**
dS, ABS		0.689*	0.679*
dN, non-ABS			0.778**

ABS: contact residues, non-ABS: non-contact residues. Effect sizes as estimated from the PGLS model that adjusted for the phylogenetic relationships of species and used statistical weights (log₁₀-sample size) in a combination that offered the best fitted to the data based on maximised log-likelihood. ***: P < 0.001; **: P < 0.01; *: P < 0.05; † < 0.1.

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