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Figure 1 | BMC Evolutionary Biology

Figure 1

From: Evolution of C2H2-zinc finger genes revisited

Figure 1

The top panel shows a maximum-likelihood tree for all the human proteins (green) encoded in cluster 19.12 and their putative chimpanzee orthologs (blue). Black circles on branches indicate aLRT branch support of 0.95 or higher. The groups from Figure 5 of Tadepally et al. [2] correspond to the leftmost seven pairs of proteins (group III), the rightmost single pair of proteins (group I), and the rest of the tree (group II). Only the ZF exon regions were used in constructing the tree (see Methods). The genome position of each ZF exon is given in the fasta name. The lower left panel shows a UCSC browser image for 28 kb around chimpanzee ZNF610, one of the genes reported as absent from chimpanzee by Tadepally et al. [2]. The track "ZNF Related Domains" shows genomic domain matches from our added track (Additional file 2); the track "Gap Locations" shows the absence of known sequence gaps in this region; the RefSeq track shows the standard UCSC alignment of human ZNF610 to the chimpanzee genome; the Ensembl track shows an Ensembl gene prediction for the chimpanzee ZNF610 ortholog; the Human Net track shows that the entire region is syntenic to human chr 19. The lower right panel shows the chimpanzee protein aligned to its human ZNF610 ortholog.

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