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Figure 9 | BMC Evolutionary Biology

Figure 9

From: Evolution of the multifaceted eukaryotic akiringene family

Figure 9

Summary of ML LRT results for Akirin1 and Akirin2 proteins mapped onto an amino acid alignment also including four invertebrate deuterostome outgroups. Sites that have evolved at the same rate in Akirin1 and 2, but at a significantly slower rate than the average for all sites, are boxed in blue. Sites with both blue and red shading correspond to positions that have evolved at either a significantly faster (red boxes) or slower (blue boxes) rate in one Akirin paralogue compared to the other. Significance is at the 5% level in all cases. Sites evolving at significantly different rates between Akirin paralogues, that were also significant in the DIVERGE [28, 33] test, are highlighted with a star. The original LRT alignment output, with 27 Akirin genes is provided in additional file 5. Shown, underlined in purple and black respectively, are two NLSs and putative 14-3-3 binding sites (after [2]). The highest scoring site (position 122, marked with black arrowhead) in both tests was a proline conserved solely in Akirin2 orthologues and Akirin proto-orthologues, but not in Akirin1 proteins. This site falls within an experimentally validated 14-3-3-recognition site [2]. Alignment name abbreviations are: P.m (P. marinus), H.s (H. sapiens), X.t (X. tropicalis), D.r (D. rerio), T.r (Takifugu rubripes), G.g (G. gallus).

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