Maximum likelihood phylogeny of the DNA topoisomerase typeIB family. Numbers indicate bootstrap support based on 100 replicates. TOP1: DNA topoisomerase 1; TOP1MT: mitochondrial DNA topoisomerase 1. Colored boxes indicate annotated and/or predicted subcellular locations of the proteins: nucleus/cytoplasm (blue) and mitochondria (green). There is no subcellular information for the proteins in Anopheles gambiae and Nematostella vectensis.