Diverse MHC IIB allele repertoire increases parasite resistance and body condition in the Long-tailed giant rat (Leopoldamys sabanus)

Table 1 Signatures of selection on the MHC class IIB loci.

Allele set	Region	# of aa sites	d_N	d_S	d_N/d_S	P
All alleles n = 28	ABS	15	0.44 ± 0.08	0.06 ± 0.03	7.60	< 0.001
	Non-ABS	42	0.13 ± 0.03	0.13 ± 0.04	1.00	0.998
	All	57	0.20 ± 0.03	0.11 ± 0.03	1.78	0.018
Alleles with deletion n = 8	ABS	15	0.19 ± 0.05	0.00 ± 0.00	na	0.002
	Non-ABS	42	0.09 ± 0.02	0.09 ± 0.04	0.94	0.865
	All	57	0.11 ± 0.02	0.06 ± 0.03	1.71	0.117

Rates of non-synonymous (d_N) versus synonymous (d_S) substitutions for the amplified part of exon 2 as well as for residues of the antigen binding site only. Data is shown for all alleles and separately for the eight alleles with the deletion. ABS - Antigen Binding Site. aa - amino acid. Significant values are marked bold.

ISSN: 2730-7182