|M. bovis||Deleted||Deleted||Deleted||plcABC part of the RD5 region (Figure 3).|
|M. bovis BCG||Deleted||Deleted||Deleted||plcABC part of the RD5 region (Figure 3).|
|CPHL_A||sSNP A → C at position 435.||+||+||All genes predicted to be fully functional.|
|K85||sSNP A → C at position 435.||+||
nsSNP C → T (Thr → Ile) at aa position 302.|
sSNP G → A at position 1506.
|plcC function possibly impaired.|
|GM041182||sSNP A → C at position 435.||+||+||All genes predicted to be fully functional.|
|M. microti||Deleted.||Deleted||5' 867 bp deleted.||plcABC part of the RD5mic region (Figure 3).|
|Oryx bacillus||Deleted||5' 260 bp deleted.||+‡||plcAB part of the RD5oryx region (Figure 3).|
|Dassie bacillus||Deleted||Deleted||Deleted||plcABC part of the RD5das region (Figure 3).|
|T17||sSNP A → C at position 435.||IS6110 insertion at position 1307.||+||plcB function predicted to be abolished.|
|EAS054||sSNP A → C at position 435.||sSNP G → A at position 1404.||+||All genes predicted to be fully functional.|
|T92||Deleted||Deleted||5' 194 bp deleted.||Major deletion results in removal of plcA, plcB and 5' region of plcC (Figure 3).|
|94_M4241A||Deleted||5' 793 bp deleted.||sSNP T→ C at position 753.||IS6110-associated recombination event has deleted plcA and 5' region of plcB (Figure 3).|
Deletion of 3' end of plcA and 5' end of plcB creates hybrid plcA/B gene. Fusion point at position 145. Results in frameshift|
and premature protein termination.
|sSNP T→ C at position 753.||Hybrid plcA/B gene predicted to be non-functional. Part of massive genome rearrangements seen in this isolate (Figure S23).|
sSNP G → A at position 705.|
nsSNP T → A (thr → ala) at position 1336.
sSNP T → C at position 753.|
nsSNP G → T (gly → cys) at position 1081.
|plcA and plcC functions possibly impaired.|
|KZN 4207||+||+||+||Total homology to H37Rv.|
|KZN 1435||+||+||+||Total homology to H37Rv.|
|KZN 605||+||+||+||Total homology to H37Rv.|
|F11||+||+||+||Total homology to H37Rv.|
|Strain C||T insertion at position 104. Altered reading frame and premature protein termination.||+||+||plcA function predicted to be abolished.|
|CDC1551||+||+||+||Total homology to H37Rv.|
|Haarlem||A insertion at position 968. Altered reading frame and premature protein termination.||+||+||plcA function predicted to be impaired.|
|H37Rv||+||+||+||Defined as wild type sequence|
|H37Ra||+||+||+||Total homology to H37Rv.|